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Stimulant-based compounds such as caffeine work by activating the central nervous system, which may temporarily increase energy expenditure and reduce appetite

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Interestingly, as shown in our transcriptome data, in addition to the pronounced enrichment of genes associated with JA signaling in systemic leaf tissues after GSH treatment, genes responsive to other defense phytohormones such as ethylene and salicylic acid, which are responsible for plant resistance to pathogen infection, are also highly upregulated (Supplementary Data 1), implying that GSH might also act as a signaling molecule to activate the plant systemic immune response

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This difference likely reflects variations in care pathways rather than direct medication effects, especially with increased medical monitoring among GLP-1RA users [4]